First detection of the equine herpesvirus 1 neuropathogenic variant in Brazil.

نویسندگان

  • E Mori
  • A S Borges
  • D J Z Delfiol
  • J P Oliveira Filho
  • R C Gonçalves
  • D Q Cagnini
  • M C C S H Lara
  • E M S Cunha
  • E M C Villalobos
  • A F C Nassar
  • A M M G Castro
  • P E Brandao
  • L J Richtzenhain
چکیده

This report describes the first detection of an equine herpesvirus 1 (EHV-1) neuropathogenic variant (G2254/D752) in Brazil from a case of fatal equine herpesvirus myeloencephalopathy (EHM) in a mare. The results of nucleotide sequencing of the EHV-1 ORF30 gene showed that two other Brazilian EHV-1 isolates from EHM cases are representatives of the non-neuropathogenic variant (A2254/N752), suggesting that other unidentified factors are probably also involved in the neuropathogenicity of EHV-1 in horses. These findings will contribute to the epidemiological knowledge of EHV-1 infection in Brazil.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Detection of the neuropathogenic variant of equine herpesvirus 1 associated with abortions in mares in Poland

BACKGROUND The incidence of reported cases of equine herpesvirus myeloencephalopathy (EHM) caused by infection with neuropathogenic strains of equine herpesvirus 1 (EHV-1) has markedly increased over the last decade in many Western countries. The purpose of this study was to estimate the prevalence of the neuropathogenic (G2254) and non-neuropathogenic (A2254) variants of EHV-1 among isolates a...

متن کامل

Immunohistochemical and molecular detection of equine herpesvirus 1 in Uruguay.

Equine herpesvirus 1 (EHV-1) is a major cause of epidemic abortion, neonatal mortality, respiratory disease and neurological disorders in horses. In South America, the virus has been isolated in Brazil, Argentina and Colombia. In Chile pathological findings from one aborted foetus have been reported, and in Uruguay only serological data about EHV-1 activity have been found. Some pathological fi...

متن کامل

A Point Mutation in a Herpesvirus Co-Determines Neuropathogenicity and Viral Shedding

A point mutation in the DNA polymerase gene in equine herpesvirus type 1 (EHV-1) is one determinant for the development of neurological disease in horses. Three recently conducted infection experiments using domestic horses and ponies failed to detect statistically significant differences in viral shedding between the neuropathogenic and non-neuropathogenic variants. These results were interpre...

متن کامل

Clinical observations and management of a severe equine herpesvirus type 1 outbreak with abortion and encephalomyelitis

Latent equine herpesvirus type 1 (EHV-1) infection is common in horse populations worldwide and estimated to reach a prevalence nearing 90% in some areas. The virus causes acute outbreaks of disease that are characterized by abortion and sporadic cases of myeloencephalopathy (EHM), both severe threats to equine facilities. Different strains vary in their abortigenic and neuropathogenic potentia...

متن کامل

Emerging and Re-emerging Viral Diseases of Large Animals

A single-nucleotide polymorphism (A(2254) or G(2254)) in the DNA polymerase gene of equine herpesvirus 1 (EHV-1) has been linked to the neuropathogenic phenotype which induces equine herpes myeloencephalitis (EHM). Based upon this, a real-time PCR assay to distinguish potentially neuropathogenic from non-neuropathogenic EHV-1 strains was described in 2007. With some limitations, this assay was ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Revue scientifique et technique

دوره 30 3  شماره 

صفحات  -

تاریخ انتشار 2011